Objective To explore the clinical effect of the treatment of primary knee osteoarthritis（Qi stagnation and blood stasis type）with self⁃made Jingu Zhitong Plaster and Huayu Tongluo Moxibustion. Methods 68 patients with primary knee osteoarthritis who met the inclusion criteria were randomly divided into treatment group and western medicine group，with 34 cases each. The western medicine group was treated with anti⁃inflamma⁃ tory and analgesic drugs combined with sodium hyaluronate injection into the joint cavity，while the treatment group was treated with self⁃made Jinggu Zhitong ointment combined with blood⁃stasis and collateral⁃removing moxi⁃ bustion，6 times a week for 2 weeks. The WOMAC bone joint scale，walking test and inflammatory index（tumor necrosis factor（TNFα），Interleukin⁃6（IL⁃6）and the incidence of adverse reactions. Results The total effective rate of the treatment group was 96.7%，which was better than that of the western medicine group（86.7%，P < 0.05）； Compared with before treatment，the knee pain score and TNFα of the two groups of patients after treatment and the inflammatory indexes of IL⁃6 were improved（P < 0.05，P < 0.01）；Compared with the western medicine group， the score of WOMAC bone joint scale and related inflammatory indexes in the treatment group were significantly improved after treatment and at the follow⁃up of one month after treatment（P < 0.01）；There was no significant difference in the incidence of adverse reactions between the treatment group（5.88%）and the western medicine group（14.70%）（P > 0.05）. Conclusion Jingu Zhitong Ointment combined with Huayu Tongluo Moxibustion can effectively reduce the joint cavity effusion and inflammatory index content in patients with primary osteoarthritis of the knee of qi stagnation and blood stasis type，improve the knee joint range of motion，relieve pain，and treat safely and effectively. The curative effect is better than that of using western medicine alone.